4 edition of Lipid Modification of Proteins found in the catalog.
Lipid Modification of Proteins
August 27, 1992
by Oxford University Press, USA
Written in English
|Contributions||N. M. Hooper (Editor), A. J. Turner (Editor)|
|The Physical Object|
|Number of Pages||312|
Given the importance of lipid-based post-translational modification of proteins, many anti-cancer therapies currently target proteins and enzymes of the prenylation pathway [87, 88]. Another type of lipid-related post-translational modification is termed acylation, which is Author: Jin Yan Lim, Hiu Yee Kwan. An important role for the membrane lipid, phosphatidylethanolamine (PE), in the functions of cell membranes and transmembrane proteins (discussed in Section ) implies that its modification affects different processes in the cell. Whereas rate constants for the reaction of HNE with amino acids have been intensively studied, no binding kinetic Author: Elena E. Pohl, Olga Jovanovic.
Increasing evidence suggests that cholesterol and sphingolipid-rich lipid microdomains or rafts exist in eukaryotic cell membranes and have important functions there ().These rafts are likely to be important in the structure and function of caveolae, plasma membrane invaginations that are implicated in signal transduction (4, 5), endocytosis (), transcytosis across endothelial cells (7, 8. Lipid modifications of proteins 8. Posttranslational proteolysis 9. Ubiquitin and ubiquitin like protein tags He has published over scientific articles and his book, Enzymatic Reaction Mechanisms, has educated generations of enzymologists. Posttranslational Modification of Proteins is the first comprehensive treatment of this.
GPI-anchored proteins are often localized to cholesterol- and sphingolipid-rich lipid rafts, which act as signaling platforms on the plasma membrane. This type of modification is reversible, as the GPI anchor can be released from the protein by phosphoinositol-specific phospholipase C. In biology and biochemistry, a lipid is a biomolecule that is soluble in nonpolar solvents. Non-polar solvents are typically hydrocarbons used to dissolve other naturally occurring hydrocarbon lipid molecules that do not (or do not easily) dissolve in water, including fatty acids, waxes, sterols, fat-soluble vitamins (such as vitamins A, D, E, and K), monoglycerides, diglycerides.
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In bacteria, an unusual but common lipid modification occurs at the N-terminus of more than proteins, resulting in the formation of a lipoprotein containing three fatty acids (Figure 5(C)) (Nakayama et al., ). Bacterial proteins destined to become lipoproteins contain an N-terminal signal peptide with a conserved sequence, termed the Cited by: 1.
Lipid Modification of Proteins: A Practical Approach (Practical Approach Series): Medicine & Health Science Books @ Modification of Lipid Metabolism is a collection of proceedings presented at the Symposium on Modification of Lipid Metabolism, held during the American Chemical Society meeting in Atlantic City, New Jersey, on September An important principle derived from studies of lipid modified proteins is that not all fat is the same.
Each type of lipid moiety is attached by a Lipid Modification of Proteins book lipid transferase and each modification confers distinct properties to the modified protein. The most common outcome of lipid modification is an increased affinity for by: 1.
Annu Rev Biochem. ; Novel lipid modifications of secreted protein signals. Mann RK(1), Beachy PA. Author information: (1)Department of Molecular Biology and Genetics and Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MarylandUSA.
[email protected] Secreted signaling proteins function in a diverse array of essential patterning Cited by: Lipid peroxidation is an important cellular process which can lead to detrimental effects if it is not regulated efficiently.
Lipid hydroperoxide is formed in an initial step of lipid peroxidation. Lipid hydroperoxide is also known as a potential source of singlet oxygen. Harmful aldehydes are.
ISBN: X OCLC Number: Description: xx, pages: illustrations ; 25 cm: Contents: Diversity of lipid modification of proteins / Anthony J. Turner --Labelling of cell proteins with radioactive fatty acids and methods for studying palmitoyl-acyl transferase / R.A.
Jeffrey McIlhinney --Methods for studying myristoyl-CoA: protein N. Book: All Authors / Contributors: Patrick J and J.E. Buss, Targeting Proteins to Membranes Using Signal Sequences for Lipid Modification.L.
Berthiaume, S.M. Peseckis, and M.D. Resh, Synthesis and Use of Iodo-Fatty Acid Analogs.R.S. Bhatnagar and J.I. Gordon, Thermodynamic Studies of Myristoyl-CoA: Protein N-Myristoyltransferase Using.
Lipid Modification of G Proteins: Subunits are Palmitoylated Article (PDF Available) in Proceedings of the National Academy of Sciences 90(8) May with 29 Reads How we measure 'reads'. Lipid modifications of proteins (Fig.
1) are widespread and functionally important in eukaryotic cells. For example, many intracellular proteins such as the signal-transducing heterotrimeric GTP-binding proteins (G proteins) and the Ras superfamily of G proteins.
The lipids connected to the glucose pathway include cholesterol and triglycerides. Cholesterol is a lipid that contributes to cell membrane flexibility and is a precursor of steroid hormones. The synthesis of cholesterol starts with acetyl groups and proceeds in only one direction.
The process cannot be reversed. The mature Hedgehog (Hh) and Sonic Hedgehog (ShH) proteins are modified by two lipid groups: N-linked palmitate at the amino terminus and a molecule of covalently bound cholesterol at the C-terminus.
Our laboratory is studying the enzymology of lipid modification of Hh. This is a very important post translation modification of proteins that diversifies proteins by enabling protein protein interactions, signal transduction and many other protein functions.
One of the widely recognized lipid linked protein is G-protein1. The pathway that proteins follow is. Figure 1: Sites of G protein lipid modification.
The N-terminal sequences of several G protein α subunits and the C-terminal sequences of two G protein subunits are shown. Two α subunits of the α i family are shown; others in this family are α, α, α, α, and α proteins contain myristate (M) linked through an amide bond to an N-terminal glycine (after removal of the initiating.
In this video we discuss the three main types of lipid modification which can be made to proteins. In book: Mass Spectrometry‐Based Chemical Proteomics, pp (PAT), one of a family of DHHC domain-containing proteins that catalyzes lipid modification of proteins.
Deletion of PFA4. Lipid Modifications of Proteins is the first single-volume publication to provide a comprehensive discussion of the five major kinds of protein-bound lipids. The book examines the biochemical activities involved in covalent attachment of different kinds of lipids to proteins, and it indicates the extent of lipid modifications to proteins.
Lipid Hydroperoxide-Derived Modification of Biomolecules. Subcellular Biochemistry (Book 77) Share your thoughts Complete your review. Tell readers what you thought by rating and reviewing this book. Rate it * You Rated it *Brand: Springer Netherlands.
The distinct nature of the lipid modification determines the strength of membrane interaction of the modified protein as well as the specificity of membrane targeting. Clusters of basic residues can also synergize with the lipophilic group to promote membrane binding and by: The book also covers the secondary adductions of these reactive species with proteins and aminophospholipids.
During lipid peroxidation, the initial event is the formation of lipid hydroperoxide, which is followed by an oxidation event that starts a : Yoji Kato.
Magee AI () Lipid modification of proteins and its relevance to protein targeting.J Cell Sci – Google Scholar Magee AI, Courtneidge SA () Two classes of fatty acylated proteins exist in eukaryotic by: 4.This modification can anchor proteins to the membrane and thioesterases can break the link between the protein and the lipid, making it an on/off switch for regulation of membrane localization [55,56].
The reversibility of palmitoylation makes it a candidate regulator for localization and function of many : Kasturi Roy, Ethan P. Marin. Posttranslational lipid modifications are important for proper localization of many proteins in eukaryotic cells.
However, the functional interrelationships between lipid modification processes in plants remain unclear. Here we demonstrate that the two heterotrimeric G-protein γ -subunits from Arabidopsis (Arabidopsis thaliana), AGG1 and AGG2, are prenylated, and AGG2 is S by: